Synthetic approaches to isocarbacyclin and analogues as potential neuroprotective agents against ischemic stroke
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چکیده
منابع مشابه
Neuroprotective Mechanisms of Taurine against Ischemic Stroke
Ischemic stroke exhibits a multiplicity of pathophysiological mechanisms. To address the diverse pathophysiological mechanisms observed in ischemic stroke investigators seek to find therapeutic strategies that are multifaceted in their action by either investigating multipotential compounds or by using a combination of compounds. Taurine, an endogenous amino acid, exhibits a plethora of physiol...
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Tissue plasminogen activator is the only US FDA-approved therapy for acute ischemic stroke treatment. There is a need for other therapies such as neuroprotective agents that can be used in acute ischemic stroke patients. Many neuroprotective agents have been shown to be promising after testing in animal models of acute stroke, but when tested in patients, efficacy signals are not consistent or ...
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BACKGROUND Kavalactones are pharmacologically active compounds present in preparations of the root trunk of Piper methysticum Forst, known as kava. This work describes the analgesic activity of some synthesized analogues of synthetic kavain, which is the main component of kava. METHODS The essays were initially performed against the writhing test in mice, and the most promising compound was a...
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ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry
سال: 2019
ISSN: 0968-0896
DOI: 10.1016/j.bmc.2018.12.010